Sat, 4 April 2009 ![]() In the second part of this finger wag at junk science journalism, we take a closer look at the reports one has to look for. It's the Lancet meta-analysis on cannabis use and the onset of psychosis whatdunnit, and responses to moral panic vary. Transforms press release,Cannabis health risks should not lead to knee jerk policy making, is a measured and sensible statement. The futile reclassification of cannabis so beloved by drug free warriors, advised against by scientists and utterly ignored by pot smokers is seen for the rhetoric it is. A federal court has taken a look at the Environmental Protection Agency's science on secondhand smoke and called it junk. Indeed, a view that is, in EPA Administrator Carol Browner's words, "widely accepted" is not the same as scientific proof. However one feels about the personal hazards of smoking, this ruling is a victory for science and against what Judge Robert Bork has called "authoritarian regulation propelled by moral intimidation." Here's the Washington Post news story, followed by a link to a Washington Times commentary piece by science author Michael Fumento.... Still, I can live with that. I may even quietly gaze intently at coffee shop menus, partaking of the delectable aroma of brewed coffee, the caress of warm carbon producing air and rejoicing at the nicotine junkies shivering on the footpath. I suppose for men, the cold helps reboot the vitality of sperm the nicotine kills. For women well, they just go old and wrinkly at breakneck speed. And that would drive anyone to smoke I guess. So, Reuters says one joint is as bad as 5 cigarettes on your lungs, when really, in every test but one, tobacco had negative effects while cannabis effects were statistically insignificant. Cannabis seems to negatively effect only one aspect of lung function, air flow. But when it comes to hyping the dangers, that single finding is sufficient to ignore the other findings and claim cannabis to be 5 times more damaging than tobacco. Notice that the Reuters' headline says 5 times even though the study says 2.5 to 5.
It seems the source of this incorrect extrapolation is here. Another more strongly worded piece on another study, from that colourful time is headed, Outrageous anti-pot lies: media uses disgraceful cancer scare tactics. The author is Paul Armentano. I respect Pauls right to be angry. For one, he's translated very difficult findings on cannabinoid behaviour across multiple disciplines, many times. Secondly the fact this junk went to press before the study was published renders the human rights and public health aim something of a joke. Reuters, Fox and even - oh, my! - Australias ABC got it very wrong. The study was welcomed by many experts, but others counselled caution. Leslie Iverson, of the University of Oxford, a member of the advisory council, said: “Despite a thorough review the authors admit that there is no conclusive evidence that cannabis use causes psychotic illness. Their prediction that 14 per cent of psychotic outcomes in young adults in the UK may be due to cannabis use is not supported by the fact that the incidence of schizophrenia has not shown any significant change in the past 30 years.” [Huffington Post article]
It takes only a short time to discover the UK government failed its public, and did so amidst calls for legalisation, all round easing of penalties and the steadily growing cries for mature policy changes. There simply is no 'pro-drug' lobby. In the ideology struggle it's war mongering, scare tactics and punitive responses, versus respect for science, human rights and harm reduction. Articles of relevance here. Comments[0] |
Sat, 14 March 2009 ![]() Welcome to a two part look at sloppy science reporting from Australias "premier flagship science programme"; Catalyst. In part one, we examine the falsehood and hype to spring from - of all things - a meta-analysis on cannabis use and psychosis, published in the Lancet in 2007. Update- June 2009: Synthetic Delta-9-THC can improve symptoms of schizophrenia. Regular readers may be familiar with the view held in the humble Firesnake Holeplex that the association between cannabis ingestion and psychotic illness is very complex. Specifically the relationship between Cannabidiol [CBD] and its proven role as an anti-psychotic. Could sufferers gravitate toward smoking for relief? Similarly, we know anandamide is lacking in individuals who experience psychotic episodes. ∆ 9-THC imitates anandamide. Again, could smokers gravitate for relief? The paper referenced above supports this view regarding ∆ 9-THC.
This Four Corners article references activity in the UK in late 2001. Despite Australian researchers favouring a cautious approach the facts have been distorted by drug-free proponents. Simply put, 'medicinal cannabis is a covert attempt to legalise cannabis by the back door'. No research, no pilot studies, no bipartisan discourse. A fact sheet here helps place things in context. The NSW cancer council have cautious information here. Ample information may be accessed here at the Medical Cannabis Information Service. In July 2003 Catalyst reported on the issue of medicinal cannabis. However, there is a more relaxed and arguably more common interpretation of the term ‘self medication’ that would strike accord with many consumers, carers and clinicians. This explanation states that people with psychotic illness use cannabis not to relieve the positive symptoms of their illness but to relieve unpleasant feelings or emotions - described in medical parlance as ‘negative symptoms’ - that may be a secondary result of their mental illness. Most people with schizophrenia would admit that cannabis use makes their hallucinations worse but research shows that a high proportion of people with schizophrenia use cannabis to cope with unpleasant feelings such as worry or boredom (Spencer in Castle & Murray, 004; Schofield et al, 006). If you also relax the requirement that the onset of mental illness must precede first cannabis use, the research does in fact support a version of the self medication hypothesis. [6. Motives influencing use of cannabis by people with psychosis: is there evidence for self medication?]
The most important problems in studying the relation between cannabis use and psychosis are reverse causality and the transitory intoxication effect.
If individuals with imminent psychotic disorder start to use cannabis to alleviate symptoms, the psychosis could be causing the cannabis use, rather than the other way around. In most of the studies included in the present meta-analysis, Theresa Moore and colleagues were able to adjust for the effect of psychotic or imminent psychotic symptoms and they were able to ensure that psychotic outcomes were not due to the transitory effect of intoxication. In observational studies, even the most thorough analysis cannot definitely rule out the possibility that confounding or bias can be responsible for the association between cannabis exposure and psychotic symptoms. However, in the present paper, the assessment of adjustment for confounding factors and transitory effects of cannabis intoxication is done more thoroughly than in previous reviews, and the odds ratio results for psychosis are more reliable and also more modest than seen in previous publications. We therefore agree with the authors’ conclusion that there is now sufficient evidence to warn young people that cannabis use will increase their risk of psychosis later in life. Oh my! The Lancet meta-analysis authors actually wrote the words "could cause...". But we see in the media release; it "will cause...". So er, which authors do they agree with? Technically, none, zip, nada, nill. A mis-trial if ever I saw one. Remember, this sad monotone topped the news releases. A meta-analysis topping media announcements? A false claim circulated to tens of thousands of trash tabloid journalists? Editors dance over submitted works for months but can't proof read their own jottings? Sigh. The future of funding research journals looks set to be complicated.
Watching the media cover marijuana is fascinating, offering deep insight into conventional wisdom, bias and failure to properly place science in context. The coverage of a new study claiming that marijuana increases the risk of later psychotic illnesses like schizophrenia by 40% displays many of these flaws. What are the key questions reporters writing about such a study need to ask? First, can the research prove causality? Most of the reporting here, to its credit, establishes at some point that it cannot,though you have to read pretty far down in some of it to understand this. You know when cannabis hits the news you’re in for a bit of fun, and this week’s story about cannabis causing psychosis was no exception. The paper was a systematic review and then a “meta-analysis” of the data which has already been collected, looking at whether people who smoke cannabis are subsequently more likely to have symptoms of “psychosis” or diagnoses of schizophrenia....
Dr Cohen: This is where dopamine is pumped out into the midbrain. In fact too much dopamine in this area is called the wind of psychotic fire.
Jonica: What a great name. Dr Cohen: And antipsychotic medications block dopamine in this region and ameliorate psychotic symptoms. Jonica: OK, so the mechanism is actually really clear, that this is how cannabis causes psychosis. Dr Cohen: That’s right.
Related articles here. Comments[0] |
Sat, 14 February 2009 ![]() The madness of reefer madness reaches fever pitch. This episode we hear how Harry J. Anslinger gets a clever idea from the "machine gun ban" to devise a truly ridiculous mode of licencing cannabis. This ensures he is able to convince Congress to pass the Marijuana Tax Act of 1937. More articles of interest are in the ever growing pile here. Comments[0] |
Sat, 31 January 2009 ![]() This March experts from around the world will meet in Vienna to decide upon the future of the War on Drugs. Other references are here. Comments[0] |






